The dynamics of histone modifications during mammalian zygotic genome activation

F Sotomayor-Lugo, N Iglesias-Barrameda… - International Journal of …, 2024 - mdpi.com
Mammalian fertilization initiates the reprogramming of oocytes and sperm, forming a
totipotent zygote. During this intricate process, the zygotic genome undergoes a maternal-to …

Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential

S Papadaki, C Piperi - International Journal of Molecular Sciences, 2024 - mdpi.com
Histone lysine methyltransferase SUV4-20H2, a member of the suppressor of variegation 4–
20 homolog (SUV4-20) family, has a critical impact on the regulation of chromatin structure …

Molecular signatures of premature aging in Major Depression and Substance Use Disorders

A Onisiforou, P Zanos, P Georgiou - Scientific Data, 2024 - nature.com
Major depressive disorder (MDD) and substance-use disorders (SUDs) often lead to
premature aging, increasing vulnerability to cognitive decline and other forms of dementia …