A review of synthetic strategy, SAR, docking, simulation studies, and mechanism of action of isoxazole derivatives as anticancer agents

GC Arya, M Khalid, S Mehla… - Journal of Biomolecular …, 2024 - Taylor & Francis
Breast cancer (BC) is a global health concern and the leading cause of cancerous death
among women across the world, BC has been characterized by fresh lump in the breast or …

Construction of Highly Functionalized C4-Oxyacylated and Aminated Pyrazolines

V Singh, BK Mishra, D Kumar, B Tiwari - Organic Letters, 2023 - ACS Publications
Pyrazolines and pyrazolones are prevalent cores in drugs and bioactive molecules.
Functionalizing them with heteroatoms on the ring improves or expands their clinical …

[HTML][HTML] Synthesis, antitumor Activity, antimicrobial evaluation and molecular docking studies of some Hydrazone, 1, 3, 4-Oxadiazole, 1, 2, 4-Triazole and pyrazole …

AR Farghaly, SA Ahmed, KS Ismail, D Ibrahim… - Results in …, 2024 - Elsevier
In this study, we synthesized a number of new intriguing azoles bearing nicotinoyl moiety,
their antimicrobial and antitumor activities were investigated as well. We succeeded to …

Evaluation of antidiabetic activity of oxadiazole derivative in rats

AI Qazi, B Ahmad, MUK Sahibzada… - Evidence‐Based …, 2023 - Wiley Online Library
The oxadiazole ring has long been used for the treatment of several diseases. This study
aimed to analyze the antihyperglycemic and antioxidant roles of the 1, 3, 4‐oxadiazole …

Imine derivatives of benzoxazole attenuate high-fat diet-induced hyperlipidemia by modulation of lipid-regulating genes

M Zaib, MNH Malik, R Shabbir, MN Mushtaq… - ACS …, 2023 - ACS Publications
Purpose: Hyperlipidemia being the prominent risk factor of cardiovascular diseases and side
effects associated with the current lipid-lowering drugs have attracted the interest of …

Diversity-oriented synthesis of 1H-1,2,3-triazole tethered pyrazolo[5,1-b]quinazoline hybrids as antimicrobial agents

DD Chudasama, MS Patel, JN Parekh, HC Patel… - Molecular Diversity, 2023 - Springer
A straightforward and high yielding synthetic approach is employed to synthesize the novel
1 H-1, 2, 3-triazole tethered pyrazolo [5, 1-b] quinazoline hybrids 7 (a–t) as new …

Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target

AF Kassem, GO Moustafa, MM Omran… - Journal of Molecular …, 2024 - Elsevier
Cancer is a common public health disease causing mortality worldwide. Thus, providing
novel chemotherapies that tackle breast cancer is of great interest. In this investigation …

Transition Metal‐Free Cycloisomerization of Propargylic Amides to Oxazoles in Hexafluoroisopropanol (HFIP)

N Jankowski, J Dietrich… - Advanced Synthesis & …, 2022 - Wiley Online Library
A transition metal‐free method for the cycloisomerization of propargylic amides to oxazoles
was developed. The reaction utilizes in situ generated hydrogen chloride in …

Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies

MB Kumar, V Hariprasad, SD Joshi, P Naik… - …, 2023 - Wiley Online Library
We present a study on a new class of Schiff bases with pyrimidine linked hydrazinyl azole
backbone. These compounds were synthesized using conventional and ultrasonication …

Diversity-oriented synthesis of 1H-1, 2, 3-triazole tethered pyrazolo [5, 1-b] quinazoline hybrids as antimicrobial agents and DFT study

DD Chudasama, MS Patel, JN Parekh, HC Patel… - 2023 - researchsquare.com
A straightforward and high yielding synthetic approach is employed to synthesize the novel
1H-1, 2, 3-triazole tethered pyrazolo [5, 1-b] quinazoline hybrids 7 (at) as new antimicrobial …