Molnupiravir: A versatile prodrug against SARS-CoV-2 variants
The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …
Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies
Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …
Vanillin-based indolin-2-one derivative bearing a pyridyl moiety as a promising anti-breast cancer agent via anti-estrogenic activity
The structure-based design introduced indoles as an essential motif in designing new
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …
Structure-based drug design of RdRp inhibitors against SARS-CoV-2
K Shehzadi, A Saba, M Yu, J Liang - Topics in Current Chemistry, 2023 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …
The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)
P Pagliano, C Sellitto, T Ascione… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Molnupiravir (MOV) is a broad-spectrum oral antiviral agent approved for the
treatment of COVID-19. The results from in vitro and in vivo studies suggested MOV activity …
treatment of COVID-19. The results from in vitro and in vivo studies suggested MOV activity …
Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as an Important Scaffold for Anticancer Drug Discovery—In Vitro and In Silico Evaluation
Pyrazolo [4, 3-e] tetrazolo [1, 5-b][1, 2, 4] triazine sulfonamides (MM-compounds) are a
relatively new class of heterocyclic compounds that exhibit a wide variety of biological …
relatively new class of heterocyclic compounds that exhibit a wide variety of biological …
Assessing the transmissibility of the new SARS-CoV-2 variants: From delta to omicron
Omicron, the latest SARS-CoV-2 Variant of Concern (VOC), first appeared in Africa in
November 2021. At present, the question of whether a new VOC will out-compete the …
November 2021. At present, the question of whether a new VOC will out-compete the …
Attenuation of quorum sensing regulated virulence functions and biofilm of pathogenic bacteria by medicinal plant Artemisia annua and its phytoconstituent 1, 8 …
The emergence of multidrug resistance (MDR) in bacterial pathogens is a serious public
health concern. A significant therapeutic target for MDR infections is the quorum sensing …
health concern. A significant therapeutic target for MDR infections is the quorum sensing …
M-polynomial and correlated topological indices of antiviral drug Molnupiravir used as a therapy for COVID-19
The coronavirus pandemic is an unending global epidemic of coronavirus disease 2019
(commonly known as, COVID-19) caused by SARS-CoV-2 (Severe Acute Respiratory …
(commonly known as, COVID-19) caused by SARS-CoV-2 (Severe Acute Respiratory …
Interaction mechanism of a pesticide, Azoxystrobin with bovine serum albumin: Assessments through fluorescence, UV–Vis absorption, electrochemical and molecular …
The current study's objective was to investigate how an antifungal pesticide Azoxystrobin
(AZO) interacts with bovine serum albumin (BSA) under conditions that simulate a …
(AZO) interacts with bovine serum albumin (BSA) under conditions that simulate a …