WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

Recent revelations that the canonical Wnt signaling pathway promotes postnatal bone
accrual are major advances in our understanding of skeletal biology and bring tremendous …

Background Osteoporosis is a major public health problem of largely unknown cause. Loss-
of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 …

Osteoporosis is a complex disease that affects> 10 million people in the United States and
results in 1.5 million fractures annually. In addition, the high prevalence of osteopenia (low …

Osteopetrosis includes a group of inherited diseases in which inadequate bone resorption is
caused by osteoclast dysfunction. Although molecular defects have been described for …

A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice
expressing this LRP5 mutation have a similar phenotype with high bone mass and …

A cDNA encoding the new member of the multispecific organic anion transporter family,
OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method …

Although the gene defects for several mouse mutants with severe osteopetrosis are known,
the genes underlying human infantile malignant recessive osteopetrosis remain elusive …

Osteoporosis is a common disease with a strong genetic component characterised by low
bone mass, microarchitectural deterioration of bone tissue and an increased risk of fracture …

To begin to develop in vivo model systems for the assessment of the contributions of specific
organic anion transporter (OAT) family members to detoxification, development, and …