Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection
A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …
three highly pathogenic variants have emerged in the 21st century. The newest member of …
SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …
[HTML][HTML] Cell entry by SARS-CoV-2
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) invades host cells by interacting
with receptors/coreceptors, as well as with other cofactors, via its spike (S) protein that …
with receptors/coreceptors, as well as with other cofactors, via its spike (S) protein that …
[HTML][HTML] Learning from the past: development of safe and effective COVID-19 vaccines
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
elicited an equally rapid response aiming to develop a COVID-19 vaccine. These efforts are …
elicited an equally rapid response aiming to develop a COVID-19 vaccine. These efforts are …
Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4+ T Cell Responses
Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …
[HTML][HTML] Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Immune profiling of COVID-19 patients has identified numerous alterations in both innate
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
[HTML][HTML] Blood DNA methylation and COVID-19 outcomes
J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …
[HTML][HTML] Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
M Severa, RA Diotti, MP Etna, F Rizzo, S Fiore… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …
Cardiac inflammation in COVID-19: Lessons from heart failure
Cardiovascular disease (CVD) is the most common co-morbidity associated with COVID-19
and the fatality rate in COVID-19 patients with CVD is higher compared to other …
and the fatality rate in COVID-19 patients with CVD is higher compared to other …
Pathogenesis‐directed therapy of 2019 novel coronavirus disease
CW Stratton, YW Tang, H Lu - Journal of medical virology, 2021 - Wiley Online Library
The 2019 novel coronavirus disease (COVID‐19) now is considered a global public health
emergency. One of the unprecedented challenges is defining the optimal therapy for those …
emergency. One of the unprecedented challenges is defining the optimal therapy for those …