Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
Advancements and hurdles in the development of a vaccine for triple-negative breast cancer: A comprehensive review of multi-omics and immunomics strategies
T Dhanushkumar, ME Santhosh, PK Selvam… - Life Sciences, 2023 - Elsevier
Abstract Triple-Negative Breast Cancer (TNBC) presents a significant challenge in oncology
due to its aggressive behavior and limited therapeutic options. This review explores the …
due to its aggressive behavior and limited therapeutic options. This review explores the …
The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN
T Jiang, J Qi, Z Xue, B Liu, J Liu, Q Hu, Y Li, J Ren… - Molecular Cancer, 2024 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) have emerged as key players in
tumorigenesis and tumour progression. However, the biological functions and potential …
tumorigenesis and tumour progression. However, the biological functions and potential …
Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers
IGF2BP1 is a protein that controls the stability, localization, and translation of various mRNA
targets. Poor clinical outcomes in numerous cancer types have been associated with its …
targets. Poor clinical outcomes in numerous cancer types have been associated with its …
Emerging Targets and Therapeutics in Immuno-Oncology: Insights from Landscape Analysis
In the ever-evolving landscape of cancer research, immuno-oncology stands as a beacon of
hope, offering novel avenues for treatment. This study capitalizes on the vast repository of …
hope, offering novel avenues for treatment. This study capitalizes on the vast repository of …
METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4
Y Zang, Z Tian, D Wang, Y Li, W Zhang, C Ma, Z Liao… - Oncogene, 2024 - nature.com
Abstract N6-methyladenosine (m6A) is the predominant post-transcriptional RNA
modification in eukaryotes and plays a pivotal regulatory role in various aspects of RNA fate …
modification in eukaryotes and plays a pivotal regulatory role in various aspects of RNA fate …
Recent advances in the reciprocal regulation of m6A modification with non-coding RNAs and its therapeutic application in acute myeloid leukemia
J Yang, F Liang, F Zhang, H Zhao, Q Gong… - Pharmacology & …, 2024 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is one of the most common modifications of RNA in
eukaryotic cells and is involved in mRNA metabolism, including stability, translation …
eukaryotic cells and is involved in mRNA metabolism, including stability, translation …
Deciphering the Divergent Gene expression landscapes of m6A/m5C/m1A methylation regulators in Hepatocellular Carcinoma through single-cell and bulk RNA …
HT Liu, CS Rau, YW Liu, TM Hsieh… - Journal of …, 2023 - Taylor & Francis
Introduction RNA modifications mediated by the m6A, m1A, and m5C regulatory genes are
crucial for the progression of malignancy. This study aimed to explore the expression of …
crucial for the progression of malignancy. This study aimed to explore the expression of …
Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer
Y Cai, Y Wang, B Mao, Q You, X Guo - European Journal of Medicinal …, 2024 - Elsevier
Insulin-like growth factor 2 mRNA-binding proteins (IMPs, IGF2BPs) are RNA-binding
proteins that regulate a variety of biological processes. In recent years, several studies have …
proteins that regulate a variety of biological processes. In recent years, several studies have …
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
L Lv, Q Wei, J Zhang, Y Dong, Z Shan, N Chang… - Cellular & Molecular …, 2024 - Springer
Background IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the
posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is …
posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is …