Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19

P Kumar Tiwari, M Chouhan, R Mishra… - Frontiers in Cellular …, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with …

[HTML][HTML] Promising Combinatorial Therapeutic Strategies against Non-Small Cell Lung Cancer

P Kaur, SK Singh, MK Mishra, S Singh, R Singh - Cancers, 2024 - mdpi.com
Simple Summary Lung cancer treatment options vary depending on the type and stage of
the cancer. For non-small cell lung cancer (NSCLC), treatments may include surgery …

[HTML][HTML] Emerging Roles of Small Extracellular Vesicles in Gastrointestinal Cancer Research and Therapy

N Schneider, PC Hermann, T Eiseler, T Seufferlein - Cancers, 2024 - mdpi.com
Simple Summary Gastrointestinal cancers originate in the digestive system and harbor
distinct characteristics according to their site of origin. This review focusses on the role of …

[HTML][HTML] Tumor-Derived Extracellular Vesicles as Liquid Biopsy for Diagnosis and Prognosis of Solid Tumors: Their Clinical Utility and Reliability as Tumor Biomarkers

P Dabral, N Bhasin, M Ranjan, MM Makhlouf… - Cancers, 2024 - mdpi.com
Simple Summary The ongoing research of extracellular vehicles (EVs including exosomes,
ectosomes, and apoptotic bodies) is gaining momentum to understand these vesicles' …

[HTML][HTML] Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation

S Hirano, Y Takefuji - Biomedicines, 2024 - mdpi.com
While drug therapy plays a crucial role in cancer treatment, many anticancer drugs,
particularly cytotoxic and molecular-targeted drugs, cause severe side effects, which often …

[HTML][HTML] Serum Insulin-like Growth Factor-Binding Protein-2 as a Prognostic Factor for COVID-19 Severity

P Mester, U Räth, S Schmid, P Amend, D Keller… - Biomedicines, 2024 - mdpi.com
Insulin-like growth factor-binding protein (IGFBP)-2 is a regulator of anabolic pathways,
which become inactivated in severe illness. Here, we measured the serum IGFBP-2 levels of …

[HTML][HTML] Potential Protective Role of Melatonin in Benign Mammary Cells Reprogrammed by Extracellular Vesicles from Malignant Cells

C Procópio de Oliveira, BM Frigieri, H Fukumasu… - Biomedicines, 2023 - mdpi.com
(1) Background: Mammary neoplasms in female dogs share many similarities with the same
tumor class in humans, rendering these animals a valuable preclinical model for studying …

[HTML][HTML] Targeting the Variants of COVID-19 via the Unlimited Approach

KM Ha - Indian Journal of Microbiology, 2023 - Springer
Coronavirus has continued to evolve and has thus caused unprecedented challenges for
human society. Multiple nations have fully or partially relied on the limited approach against …

[HTML][HTML] The arising role of extracellular vesicles in cholangiocarcinoma: a rundown of the current knowledge regarding diagnostic and therapeutic approaches

EM Trifylli, AG Kriebardis, E Koustas… - International Journal of …, 2023 - mdpi.com
Cholangiocarcinomas (CCAs) constitute a heterogeneous group of highly malignant
epithelial tumors arising from the biliary tree. This cluster of malignant tumors includes three …

[HTML][HTML] Improved survival of SARS COV-2-infected K18-hACE2 mice treated with adenosine A2AR agonist

BJ Mann, P Chhabra, M Ma, SG Brovero, RT Hannan… - Heliyon, 2023 - cell.com
A life-threatening manifestation of Covid-19 infection is a cytokine storm that requires
hospitalization and supplemental oxygen. Various strategies to reduce inflammatory …