Real-world effectiveness of nirmatrelvir/ritonavir against COVID-19 hospitalizations and severe COVID-19 in community-dwelling elderly Singaporeans during …

LE Wee, AT Tay, C Chiew, BE Young, B Wong… - Clinical Microbiology …, 2023 - Elsevier
Objectives Real-world data on continued effectiveness of nirmatrelvir/ritonavir against
hospitalization and severe COVID-19 in the context of widespread booster mRNA vaccine …

Clinical effectiveness of oral antiviral agents in older patients with COVID‐19 based on real‐world data

YW Tsai, JY Wu, TH Liu, MH Chuang… - Journal of medical …, 2023 - Wiley Online Library
Several randomized controlled trials and real‐world cohort studies have demonstrated the
efficacies of nirmatrelvir plus ritonavir (NMV‐r) and molnupiravir (MOV) in at‐risk patients …

[HTML][HTML] Protective effect of ursodeoxycholic acid on COVID-19 in patients with chronic liver disease

Y Li, N Zhu, X Cui, Y Lin, X Li - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Objective: Ursodeoxycholic acid (UDCA) may reduce susceptibility to severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) infection by downregulating host …

Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated …

SE Smith-Jeffcoat, JE Biddle, HK Talbot… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Nirmatrelvir/ritonavir (N/R) reduces severe outcomes from coronavirus
disease 2019 (COVID-19); however, rebound after treatment has been reported. We …

Effectiveness, tolerability and prescribing choice of antiviral molecules molnupiravir, remdesivir and nirmatrelvir/r: a real-world comparison in the first ten months of use

C Del Borgo, S Garattini, C Bortignon, A Carraro… - Viruses, 2023 - mdpi.com
In 2022, three antiviral drugs—molnupiravir, remdesivir and nirmatrelvir/ritonavir—were
introduced for treatment of mild-to-moderate COVID-19 in high-risk patients. The aim of this …

Real-world Effectiveness of Molnupiravir and Nirmatrelvir/Ritonavir as Treatments for COVID-19 in Patients at High Risk

D Paraskevis, M Gkova, K Mellou… - The Journal of …, 2023 - academic.oup.com
Background Using a retrospective cohort study design, we aimed to evaluate the
effectiveness of molnupiravir and nirmatrelvir/ritonavir in patients with SARS-CoV-2 who …

China's COVID-19 reopening measures—warriors and weapons

S Huang, Z Gao, S Wang - The Lancet, 2023 - thelancet.com
China's COVID-19 reopening measures�warriors and weapons Page 1
Correspondence www.thelancet.com Vol 401 February 25, 2023 643 his inauguration. We …

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation

M Liu, B Lu, Y Li, S Yuan, Z Zhuang, G Li… - … and Targeted Therapy, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), has had a significant impact on healthcare systems …

Efficacy and safety of antiviral treatments for symptomatic COVID-19 outpatients: Systematic review and network meta-analysis

M Zur, T Peselev, S Yanko, V Rotshild, I Matok - Antiviral Research, 2023 - Elsevier
Background Remdesivir, molnupiravir, and nirmatrelvir/ritonavir are three antiviral agents
approved by FDA emergency authorization for treating mild to moderate symptomatic COVID …

The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses

EA Meyerowitz, Y Li - Clinical Infectious Diseases, 2024 - academic.oup.com
The goals of coronavirus disease 2019 (COVID-19) antiviral therapy early in the pandemic
were to prevent severe disease, hospitalization, and death. As these outcomes have …