Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches: a systematic review of published models, applications, and model verification
JE Sager, J Yu, I Ragueneau-Majlessi… - Drug Metabolism and …, 2015 - ASPET
Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …
development, clinical study design and regulatory review, and the number of physiologically …
Escitalopram in adolescents with generalized anxiety disorder: a double-blind, randomized, placebo-controlled study
Background: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat
pediatric anxiety disorders, including generalized anxiety disorder (GAD); however, their …
pediatric anxiety disorders, including generalized anxiety disorder (GAD); however, their …
Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections
KM Job, J Olson, C Stockmann… - Expert review of anti …, 2016 - Taylor & Francis
Introduction: Voriconazole is a broad-spectrum antifungal agent commonly used to treat
invasive fungal infections (IFI), including aspergillosis, candidiasis, Scedosporium infection …
invasive fungal infections (IFI), including aspergillosis, candidiasis, Scedosporium infection …
CYP2C19-guided escitalopram and sertraline dosing in pediatric patients: a pharmacokinetic modeling study
Abstract Objective: Cytochrome P4502C19 (CYP2C19) is a highly polymorphic gene that
encodes an enzyme that metabolizes escitalopram and sertraline, two selective serotonin …
encodes an enzyme that metabolizes escitalopram and sertraline, two selective serotonin …
Development of physiology based pharmacokinetic model to predict the drug interactions of voriconazole and venetoclax
J Dong, S Liu, JM Rasheduzzaman, C Huang… - Pharmaceutical …, 2022 - Springer
Purpose Venetoclax (VEN), an anti-tumor drug that is a substrate of cytochrome P450 3A
enzyme (CYP3A4), is used to treat leukemia. Voriconazole (VCZ) is an antifungal …
enzyme (CYP3A4), is used to treat leukemia. Voriconazole (VCZ) is an antifungal …
Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity
P Zubiaur, P Soria‐Chacartegui… - Clinical …, 2023 - Wiley Online Library
A novel haplotype composed of two non‐coding variants, CYP2C18 NM_000772. 3: c.* 31T
(rs2860840) and NM_000772. 2: c. 819+ 2182G (rs11188059), referred to as “CYP2C: TG,” …
(rs2860840) and NM_000772. 2: c. 819+ 2182G (rs11188059), referred to as “CYP2C: TG,” …
Assessing pharmacokinetic differences in Caucasian and East Asian (Japanese, Chinese and Korean) populations driven by CYP2C19 polymorphism using …
Understanding the influence of ethnicity on drug exposure is key to patient safety and could
minimize repetitive clinical studies. This analysis aimed to evaluate the ability of …
minimize repetitive clinical studies. This analysis aimed to evaluate the ability of …
Selective serotonin reuptake inhibitor pharmacokinetics during pregnancy: clinical and research implications
EA Poweleit, MA Cinibulk, SA Novotny… - Frontiers in …, 2022 - frontiersin.org
Pregnancy and associated physiologic changes affect the pharmacokinetics of many
medications, including selective serotonin reuptake inhibitors—the first-line pharmacologic …
medications, including selective serotonin reuptake inhibitors—the first-line pharmacologic …
Pharmacogenetically guided escitalopram treatment for pediatric anxiety disorders: protocol for a double-blind randomized trial
Current pharmacologic treatments for pediatric anxiety disorders (eg, selective serotonin
reuptake inhibitors (SSRIs)) frequently use “one size fits all” dosing strategies based on …
reuptake inhibitors (SSRIs)) frequently use “one size fits all” dosing strategies based on …
Application of a physiologically based pharmacokinetic model to characterize time-dependent metabolism of voriconazole in children and support dose optimization
Y Zhang, S Zhao, C Wang, P Zhou… - Frontiers in Pharmacology, 2021 - frontiersin.org
Background: Voriconazole is a potent antifungal drug with complex pharmacokinetics
caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also …
caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also …