Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo

ML Risner, M Ribeiro, NR McGrady… - Cell Communication and …, 2023 - Springer
Background Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the
prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling …

Cilastatin as a Potential Anti-Inflammatory and Neuroprotective Treatment in the Management of Glaucoma

MA Martínez-López, S Rubio-Casado… - International Journal of …, 2024 - mdpi.com
Glaucoma is a neurodegenerative disease that causes blindness. In this study, we aimed to
evaluate the protective role of cilastatin (CIL), generally used in the treatment of …

[HTML][HTML] Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy

AM Boal, NR McGrady, X Chamling… - … Vision Science & …, 2023 - iovs.arvojournals.org
Purpose: Axons depend on long-range transport of proteins and organelles which increases
susceptibility to metabolic stress in disease. The axon initial segment (AIS) is particularly …

Estudio de la respuesta inflamatoria en el sistema nervioso central tras el aplastamiento completo del nervio óptico en ratón

JM Cabrera Maqueda - Proyecto de investigación, 2023 - digitum.um.es
Objetivos El aplastamiento del nervio óptico (ApNO) produce una reacción inflamatoria que
se extiende a la retina lesionada y la contralateral. Sin embargo, la propagación de la …

Muster des retinalen Ganglienzellverlustes im experimentellen Glaukommodell

J Kern - 2024 - kups.ub.uni-koeln.de
Hintergrund: Das Glaukom umfasst eine Gruppe von Augenerkrankungen, die mit einer
irreversiblen Erblindung einhergehen. Dabei ist der erhöhte Augeninnendruck beim …

Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell

TE Zapadka, NM Tran, JB Demb - bioRxiv, 2024 - biorxiv.org
Retinal ganglion cells (RGCs) are the sole output neurons of the retina and convey visual
information to the brain via their axons in the optic nerve. Following an injury to the optic …

Retinal Ganglion Cell Excitability and Adaptations to Ionic Stress in Glaucomatous Optic Neuropathy

A Boal - 2023 - ir.vanderbilt.edu
Neurodegenerative diseases are complex disorders that affect various regions and cells in
the central nervous system, sharing common hallmark features of progression. Intrinsic and …