Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF …

YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - Mutation Research …, 2001 - Elsevier
A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis

H Hausen - Journal of the National Cancer Institute, 2000 - academic.oup.com
During the past 20 years, several types of human papillomaviruses (HPVs) have been
identified that cause specific types of cancers. The etiology of cancer of the cervix has been …

Multifaceted link between cancer and inflammation

G Sethi, MK Shanmugam, L Ramachandran… - Bioscience …, 2012 - portlandpress.com
Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-κB-responsive genes in …

M Nees, JM Geoghegan, T Hyman, S Frank… - Journal of …, 2001 - Am Soc Microbiol
Infection with high-risk human papillomaviruses (HPV) is a major risk factor for development
of cervical cancer. Expression of the HPV E6 and E7 oncoproteins increases in …

The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance

MW Mayo, AS Baldwin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2000 - Elsevier
Discovered in 1986 as a DNA binding activity that recognized the immunoglobulin light
chain intronic enhancer, NF-κB has been studied intensively for its role in controlling …

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

S Mishra, C Cosentino, AK Tamta, D Khan… - Nature …, 2022 - nature.com
Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle
wasting in mammals. However, the molecular events that mediate glucocorticoid-induced …

Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases

M Ramalingam, SJ Kim - Journal of Neural Transmission, 2012 - Springer
The continuous production and efflux of reactive oxygen/nitrogen species from endogenous
and exogenous sources can damage biological molecules and initiate a cascade of events …

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

MR Young, JJ Li, M Rincón… - Proceedings of the …, 1999 - National Acad Sciences
Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …

Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure–activity relationship and molecular mechanisms

DX Hou, K Kai, JJ Li, S Lin, N Terahara… - …, 2004 - academic.oup.com
Anthocyanins are the chemical components that give the intense color to many fruits and
vegetables, such as blueberries, red cabbages and purple sweet potatoes. Extensive …

Protein kinases and transcription factors activation in response to UV-radiation of skin: Implications for carcinogenesis

C López-Camarillo, EA Ocampo… - International journal of …, 2011 - mdpi.com
Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune
suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the …