Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

O Rho, DJ Kim, K Kiguchi… - Molecular …, 2011 - Wiley Online Library
Growth factor receptor (GFR) signaling controls epithelial cell growth by responding to
various endogenous or exogenous stimuli and subsequently activating downstream …

Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-κB signalling …

I Das, A Acharya, DL Berry, S Sen, E Williams… - British journal of …, 2012 - cambridge.org
The role of dietary factors in inhibiting or delaying the development of non-melanoma skin
cancer (NMSC) has been investigated for many years. Cardamom, which is a dietary …

SNIP1 inhibits NF-κB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators

RH Kim, KC Flanders, SB Reffey, LA Anderson… - Journal of Biological …, 2001 - ASBMB
SNIP1 is a 396-amino acid nuclear protein shown to be an inhibitor of the TGF-β signal
transduction pathway and to be important in suppressing transcriptional activation …

Vanadate-induced activation of activator protein-1: role of reactive oxygen species

M Ding, JJ Li, SS Leonard, JP Ye, X Shi… - …, 1999 - academic.oup.com
The present study was undertaken to test the hypothesis that the toxicity and carcinogenicity
of vanadium might arise from elevation of reactive oxygen species leading to activation of …

Size-dependent effects of tungsten carbide–cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells

M Ding, ER Kisin, J Zhao, L Bowman, Y Lu… - Toxicology and applied …, 2009 - Elsevier
Hard metal or cemented carbide consists of a mixture of tungsten carbide (WC)(85%) and
metallic cobalt (Co)(5–15%). WC–Co is considered to be potentially carcinogenic to …

Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells

KH Lee, JR Kim - Clinical & experimental metastasis, 2012 - Springer
Blocking of activator protein-1 activity leads to suppression of growth factor-induced
transformation. However, the role of individual components of the Jun family in this process …

Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1

CC Wang, MF Tsai, TH Dai, TM Hong, WK Chan… - Cancer research, 2007 - AACR
HLJ1 is a novel tumor and invasion suppressor that inhibits tumorigenesis and cancer
metastasis. However, the mechanism of HLJ1 activation is currently unclear. Here, we …

[HTML][HTML] Diindolylmethane alters gene expression in human keratinocytes in vitro

TH Carter, K Liu, W Ralph Jr, DZ Chen, M Qi, S Fan… - The Journal of …, 2002 - Elsevier
Indole-3-carbinol (I3C) and its dimer 3, 3′-diindolylmethane (DIM), obtained from dietary
consumption of cruciferous vegetables, have multiple biochemical activities. Both …

Coactivation of ATM/ERK/NF-κB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes

KM Ahmed, D Nantajit, M Fan, JS Murley… - Free Radical Biology …, 2009 - Elsevier
Elucidating the molecular mechanism of the low-dose radiation (LDR)-mediated
radioadaptive response is crucial for inventing potential therapeutic approaches to …

Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells

AP Lu, F Zhang, A Gupta, J Liu - Journal of Biological Chemistry, 2002 - ASBMB
Breast cancer-specific gene 1 (BCSG1) is not expressed in normal breast tissue but is highly
expressed in the vast majority of invasive and metastatic breast carcinomas. When over …