[HTML][HTML] Immune responses to injury and their links to eye disease

MANN Stepp, ASUE Menko - Translational Research, 2021 - Elsevier
The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering

JR Tribble, F Hui, H Quintero, S El Hajji, K Bell… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

[HTML][HTML] Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells

WK Ju, GA Perkins, KY Kim, T Bastola, WY Choi… - Progress in Retinal and …, 2023 - Elsevier
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

Nanozyme‐Cosmetic Contact Lenses for Ocular Surface Disease Prevention

Q Liu, S Zhao, Y Zhang, Q Fang, W Liu… - Advanced …, 2023 - Wiley Online Library
Efficiently balancing excess reactive oxygen species (ROS) caused by various factors on the
ocular surface is a promising strategy for preventing the development of ocular surface …

Amination-mediated nano eye-drops with enhanced corneal permeability and effective burst release for acute glaucoma treatment

DD Nguyen, CH Yao, SJ Lue, CJ Yang, YH Su… - Chemical Engineering …, 2023 - Elsevier
The development of topical formulations with advanced functions to overcome the poor and
sluggish permeability/bioavailability of traditional eye drops into interior of the eye is …

Role of oxidative stress in retinal disease and the early intervention strategies: a review

J Wang, M Li, Z Geng, S Khattak, X Ji… - … Medicine and Cellular …, 2022 - Wiley Online Library
The retina, owing to its cellular anatomy and physical location, is susceptible to generating
reactive oxygen species (ROS), which are associated with several major retinal diseases …

TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

Q Li, Y Cheng, S Zhang, X Sun, J Wu - Journal of neuroinflammation, 2021 - Springer
Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type of
retinal disease characterized by the selective death of retinal ganglion cells (RGCs) …

Role of oxidative stress in ocular diseases: a balancing act

DY Shu, S Chaudhary, KS Cho, A Lennikov, WP Miller… - Metabolites, 2023 - mdpi.com
Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Glial cells in glaucoma: friends, foes, and potential therapeutic targets

MY García-Bermúdez, KK Freude… - Frontiers in …, 2021 - frontiersin.org
Glaucoma is the second leading cause of blindness worldwide, affecting~ 80 million people
by 2020 (,). The condition is characterized by a progressive loss of retinal ganglion cells …

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

JR Soucy, EA Aguzzi, J Cho, MJ Gilhooley… - Molecular …, 2023 - Springer
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …