The integrins are a family of transmembrane heterodimeric adhesion molecules that play
important roles in wound healing, immune system function and organ development. Recent …

Leukocytes circulate freely in the bloodstream until receiving signals which activate
adhesive mechanisms essential for immune responsiveness. Key mediators of these …

Selectins have previously been shown to tether a flowing leukocyte to a vessel wall and
mediate rolling. Here, we report that an intergrin, VLA-4, can also support tethering and …

The interaction of the α 5 β 1 integrin and its ligand, fibronectin (FN), plays a crucial role in
the adhesion of cells to the extracellular matrix. An important intrinsic property of the α 5 β …

Vascular endothelial cadherin (VE-cadherin) is an endothelial cell–specific cadherin that
plays an important role in the control of vascular organization. Blocking VE-cadherin …

The reorganization of extracellular matrix (ECM) is an important function in many biological
and pathophysiological processes. Culture of fibroblasts in a three-dimensional collagenous …

Expression of a constitutively active R-ras converted two cell lines that grow in suspension
into highly adherent cells. There was little change in cell surface expression of integrins, but …

The very late activation antigens (VLA) or β1 integrins mediate cell attachment to different
extracellular matrix proteins and intercellular adhesions. The ligand binding activity of these …

The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally
upregulated in the vasculature of solid tumors, but its functional role in tumor angiogenesis …

The plasma protein fibronectin is an important opsonin in wound repair and host defense. To
better understand the process of fibronectin-mediated phagocytosis, we have transfected …