Type 1 diabetes is caused by a deficiency of insulin secretion which has been considered
traditionally as the outcome of a precipitous decline in the viability of β-cells in the islets of …

Tertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-
lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines IL-1β and …

Introduction Despite the improvements of insulin therapy, people with type 1 diabetes (T1D)
still suffer from a decreased quality of life and life expectancy. The search toward a cure for …

Aim The variation in quality between the human islet samples represents a major problem
for research, especially when used as control material. The assays assessing the quality of …

Aims/hypothesis Type 1 diabetes is an heterogenous condition. Characterising factors
explaining differences in an individual's clinical course and treatment response will have …

Noel G. Morgan (Redondo, MJ, Morgan, NG Heterogeneity and endotypes in type 1
diabetes mellitus. Nat. Rev. Endocrinol. 19, 542–554 (2023)) 1. The authors propose a new …

The diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin‐
dependent diabetes mellitus; SPIDDM) have been revised by the Committee on Type 1 …

Hypoglycemia in type 1 diabetes associates with changes in the pancreatic islet α cells,
where the receptor for advanced glycation end products (RAGE) is highly expressed. This …

Aims This review aims to introduce research in the pancreas to a broader audience. The
pancreas is a heterocrine gland residing deep within our abdominal cavity. It is the home to …