The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …

Both aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key
regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a …

The functional interdependencies between the molecular components of a biological
process demands for a network medicine platform that integrates systems biology and …

The molecular mechanisms and signal transduction cascades evoked by the activation of
aryl hydrocarbon receptor (AhR) are becoming increasingly understandable. AhR is a ligand …

A dozen bHLH-PAS transcription factors have evolved since the dawn of the animal
kingdom; nine of them have mutual orthologs between arthropods and vertebrates. These …

Background: Patients with alcohol-associated hepatitis (AH) have an altered fecal
metabolome, including reduced microbiota-derived tryptophan metabolites which function …

Diabetic retinopathy (DR) is a severe consequence of long-term diabetes mellitus and may
lead to vision loss. Retinal pigment epithelial (RPE) cells are a diverse group of retinal cells …

The conceptualization of polycystic ovary syndrome (PCOS) has primarily focused on
hormonal alterations driven by changes within the hypothalamus and ovarian granulosa …

Early life exposure lays the groundwork for the risk of developing cardiovascular–kidney–
metabolic (CKM) syndrome in adulthood. Various environmental chemicals to which …

Stem cells are ubiquitously found in various tissues and organs in the body, and underpin
the body's ability to repair itself following injury or disease initiation, though repair can …