Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Reactive species play an important role in physiological functions. Overproduction of
reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the …

Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …

The era of the aging society has arrived, and this is accompanied by an increase in the
absolute numbers of patients with neurological disorders, such as Alzheimer's disease (AD) …

Purpose The purpose of this study was to investigate the effects of obesity and aerobic
exercise training on oxidant–antioxidant balance, neurotrophic factor levels, and blood …

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing
brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer's …

Oxidative stress is an important cause of dopaminergic (DA) neuron apoptosis in
Parkinson's disease (PD). Mesenchymal stromal cells (MSCs) possess antioxidative …

Abstract P‐glycoprotein (P‐gp) is an efflux transporter at the blood–brain barrier (BBB) that
hinders brain access of substrate drugs and clears endogenous molecules such as amyloid …

The central nervous system (CNS) is a mythical target for drug delivery. There is an ongoing
debate over the brain accessibility of flavonoids, a group of plant-derived secondary …

Interrogation of the molecular makeup of the blood–brain barrier (BBB) using proteomic
techniques has contributed to the cataloguing and functional understanding of the proteins …