Interdisciplinary Applied Mathematics

SSAJE Marsden, LSS Wiggins, L Glass, RV Kohn… - 2002 - Springer
The theory of branching processes is an area of mathematics that describes situations in
which an entity exists for a time and then may be replaced by one, two, or more entities of a …

Cancer stem cell division: when the rules of asymmetry are broken

S Mukherjee, J Kong, DJ Brat - Stem cells and development, 2015 - liebertpub.com
Asymmetric division of stem cells is a highly conserved and tightly regulated process by
which a single stem cell produces two daughter cells and simultaneously directs the …

Investigating biocomplexity through the agent-based paradigm

H Kaul, Y Ventikos - Briefings in Bioinformatics, 2015 - academic.oup.com
Capturing the dynamism that pervades biological systems requires a computational
approach that can accommodate both the continuous features of the system environment as …

[HTML][HTML] Stem cells with neural crest characteristics derived from the bulge region of cultured human hair follicles

H Yu, SM Kumar, AV Kossenkov, L Showe… - Journal of investigative …, 2010 - Elsevier
In this study, we demonstrate that we can isolate stem cells (SCs) with neural crest
characteristics from the bulge area of cultured human hair follicles (HFs). These SCs can …

Blood cell dynamics: half of a century of modelling

L Pujo-Menjouet - Mathematical Modelling of Natural …, 2016 - mmnp-journal.org
The objective of this paper is to give a review of the main works dealing with mathematical
modeling of blood cell formation, disorders and treatments within the past fifty years. From …

[HTML][HTML] Noise-driven stem cell and progenitor population dynamics

M Hoffmann, HH Chang, S Huang, DE Ingber… - PLoS …, 2008 - journals.plos.org
Background The balance between maintenance of the stem cell state and terminal
differentiation is influenced by the cellular environment. The switching between these states …

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation

B Mizukawa, E O'Brien, DC Moreira… - Blood, The Journal …, 2017 - ashpublications.org
As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly controlled in
maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions. We found that …

[HTML][HTML] Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex vivo …

N Alakel, D Jing, K Muller, M Bornhauser… - Experimental …, 2009 - Elsevier
OBJECTIVE: To investigate the impact of direct contact between mesenchymal stromal cells
(MSCs) and CD133+ hematopoietic stem cells in terms of expansion potential …

[HTML][HTML] Automated segmentation of fluorescence microscopy images for 3D cell detection in human-derived cardiospheres

M Salvi, U Morbiducci, F Amadeo, R Santoro… - Scientific reports, 2019 - nature.com
The 'cardiosphere'is a 3D cluster of cardiac progenitor cells recapitulating a stem cell niche-
like microenvironment with a potential for disease and regeneration modelling of the failing …

Mathematical modeling of monoclonal conversion in the colonic crypt

AG Fletcher, CJW Breward, SJ Chapman - Journal of theoretical biology, 2012 - Elsevier
A novel spatial multiscale model of a colonic crypt is described, which couples the cell cycle
(including cell division) with the mechanics of cell movement. The model is used to …