Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Physiological anti-inflammatory mechanisms are selected by evolution to effectively control
the immune system and can be exploited for the treatment of inflammatory disorders. Recent …

Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a
decisive role in the pathogenesis of several neurodegenerative disorders. Activated …

Abstract Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune
responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed …

Lipid metabolism is of particular interest due to its high concentration in CNS. The
importance of lipids in cell signaling and tissue physiology is demonstrated by many CNS …

Brain development is a sequential anatomical process characterised by specific well-
defined stages of growth and maturation. One of the fundamental and necessary events in …

Background Helicobacter pylori has changed radically gastroenterologic world, offering a
new concept in patients' management. Over time, more medical data gave rise to diverse …

5 Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanaham TK, Zurawski G,
Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like …

Background The activation of the immune system in neurodegeneration has detrimental as
well as beneficial effects. Which aspects of this immune response aggravate the …

Previously, we have reported that there is a spatiotemporal relationship between iron
accumulation in microglia and oligodendrocytes during normal development and in …