Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

Kidney disease is a global health problem with high mortality and socioeconomic burden,
including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy …

Sepsis-induced cardiomyopathy (SIC) is a serious complication of sepsis with high mortality
but no effective treatment. The renin angiotensin (Ang) aldosterone system (RAAS) is …

Diabetic wound management still faces great challenges mainly due to immune disorders at
wound area. Especially, macrophage polarization toward M2 phenotype is severely …

There are still challenges in applying drug nanocarriers for in situ sustained macrophage
targeting and regulation, due to the rapid clearance of nanocarriers and burst drug release …

Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel
therapeutic tool for preventing human diseases. However, the number of well-verified plant …

Sepsis presents as a severe infectious disease frequently documented in clinical settings.
Characterized by its systemic inflammatory response syndrome, sepsis has the potential to …

Liver, as an immune and detoxification organ, represents an important line of defense
against bacteria and infection and a vulnerable organ that is easily injured during sepsis …

Macrophages are present in almost all body tissues. They detect and quickly respond to
“environmental signals” in the tissue. Macrophages have been associated with numerous …

Background There is no available viable treatment for Sepsis-Induced Cardiomyopathy
(SIC), a common sepsis complication with a higher fatality risk. The septic patients showed …