As populations age worldwide, the burden of valvular heart disease has grown
exponentially, and so has the proportion of affected women. Although rheumatic valve …

Despite numerous promising therapeutic targets, there are no proven medical treatments for
calcific aortic stenosis (AS). Multiple stakeholders need to come together and several …

Objective: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic
valve stenosis progression, which further promotes fibrosis or even differentiate into …

Objectives To investigate the prevalence and quantity of aortic valve calcium (AVC) in two
large cohorts, stratified according to age and lipoprotein (a)(Lp (a)), and to assess the …

Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed
world with currently no effective pharmacological treatment available. CAVD results from a …

Objective To assess whether patients with aortic valve stenosis (AS) with elevated
lipoprotein (a)(Lp (a)) are characterised by increased valvular calcification activity compared …

Our perspectives on aortic stenosis (AS) are changing. Evolving from the traditional thought
of a passive degenerative disease, developing a greater understanding of the condition's …

Aortic stenosis is a common condition associated with major morbidity, mortality, and health-
care costs. Nevertheless, we currently lack any effective medical therapies that can treat or …

Lipid droplets (LDs) have been regarded as potential targets for the diagnosis of
cardiovascular diseases. However, conventional LDs imaging strategies suffer from invasive …

One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was
detected in all stages of aortic valve sclerosis and was demonstrated to trigger the activation …