Countermeasures are desirable to retard bone loss during long-term space flight. We
evaluated the effect of an intervention protocol on bed rest-induced bone loss. Introduction …

Low intensity pulsed ultrasound (LIPUS) was proven to enhance fracture healing effectively.
Similar effect of LIPUS on accelerating the osteoporotic fracture healing was therefore …

Background Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-
magnitude whole-body vibration (WBV) exercise has been developed as a potential …

Low-magnitude high-frequency vibration (LMHFV) has been proven to promote osteoporotic
fracture healing. Mechanical stimulation was reported to enhance SDF-1/CXCR4 signalling …

The objective of this study is to examine the effect of low-magnitude, high-frequency (LMHF)
loading, and anti-osteoporosis medications such as parathyroid hormone (PTH) and …

Estrogen receptor (ER) in ovariectomy-induced osteoporotic fracture was reported to exhibit
delayed expression. Mechanical stimulation enhanced ER-α expression in osteoporotic …

Mechanical loading allows both investigation into the mechano-regulation of fracture
healing as well as interventions to improve fracture-healing outcomes such as delayed …

A balanced inflammatory response is important for successful fracture healing. The
response of osteoporotic fracture healing is deranged and an altered inflammatory response …

Fracture healing is regulated by mechanical loading. Understanding the underlying
mechanisms during the different healing phases is required for targeted mechanical …

Most osteoporotic fractures occur at metaphyseal regions of long bones. The present study
proposed a clinically relevant animal model that satisfied: i) induction of osteoporosis, ii) …