Estrogen receptor α-(ERα), but not ERβ-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration

M Haffner-Luntzer, A Kovtun, I Lackner, Y Mödinger… - Bone, 2018 - Elsevier
Mechanostimulation by low-magnitude high frequency vibration (LMHFV) has been shown
to provoke anabolic effects on the intact skeleton in both mice and humans. However …

Effect of low-level mechanical vibration on osteogenesis and osseointegration of porous titanium implants in the repair of long bone defects

D Jing, S Tong, M Zhai, X Li, J Cai, Y Wu, G Shen… - Scientific Reports, 2015 - nature.com
Emerging evidence substantiates the potential of porous titanium alloy (pTi) as an ideal
bone-graft substitute because of its excellent biocompatibility and structural properties …

[HTML][HTML] De-osteogenic-differentiated mesenchymal stem cells accelerate fracture healing by mir-92b

Y Hou, W Lin, Y Li, Y Sun, Y Liu, C Chen… - Journal of orthopaedic …, 2021 - Elsevier
Abstract Background Mesenchymal stem cells (MSCs) are promising targets for therapeutic
use in regenerative medicine and tissue engineering. In the previous study, we have found …

Can we enhance osteoporotic metaphyseal fracture healing through enhancing ultrastructural and functional changes of osteocytes in cortical bone with low …

MHV Choy, RMY Wong, MC Li, BY Wang… - The FASEB …, 2020 - Wiley Online Library
Fragility fractures are related to the loss of bone integrity and deteriorated morphology of
osteocytes. Our previous studies have reported that low‐magnitude high‐frequency …

Vibration therapy as an effective approach to improve bone healing in diabetic rats

MS Campos, JB Volpon, JPB Ximenez… - Frontiers in …, 2022 - frontiersin.org
Objective To investigate the effects of vibration therapy on fracture healing in diabetic and
non-diabetic rats. Methods 148 rats underwent fracture surgery and were assigned to four …

Low‑level mechanical vibration enhances osteoblastogenesis via a canonical Wnt signaling‑associated mechanism

H Gao, M Zhai, P Wang, X Zhang… - Molecular …, 2017 - spandidos-publications.com
Osteoporosis is a skeletal metabolic disease characterized by reduced bone mass and a
high susceptibility to fractures, in which osteoblasts and osteoclasts are highly involved in …

Callus formation is related to the expression ratios of estrogen receptors-alpha and-beta in ovariectomy-induced osteoporotic fracture healing

SK Chow, K Leung, L Qin, F Wei, W Cheung - Archives of orthopaedic and …, 2014 - Springer
Introduction This study characterizes ovariectomized (OVX)-induced osteoporotic fracture
healing with focus on estrogen receptors (ERs). Callus formation plays a critical role in …

Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of β-catenin signaling pathway

W Hou, D Zhang, X Feng, Y Zhou - Archives of oral biology, 2020 - Elsevier
Abstract Objective Mesenchymal stem cells (MSCs) are well known to have the capability to
form bone and cartilage, and chondrogenesis derived from MSCs is reported to be affected …

Strain and vibration in mesenchymal stem cells

B McClarren, R Olabisi - International Journal of Biomaterials, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into any
mesenchymal tissue, including bone, cartilage, muscle, and fat. MSC differentiation can be …

[HTML][HTML] Enhancement of osteoporotic fracture healing by vibration treatment: the role of osteocytes

WH Cheung, RMY Wong, VMH Choy, MCM Li… - Injury, 2021 - Elsevier
The prevalence of osteoporotic fracture is high due to global aging problem. Delayed and
impaired healing in osteoporotic fractures increase the socioeconomic burden significantly …