ED Lobo, RJ Hansen, JP Balthasar - Journal of pharmaceutical sciences, 2004 - Elsevier
Abstract The US Food and Drug administration (FDA) has approved several polyclonal antibody preparations and at least 18 monoclonal antibody preparations (antibodies …
M Millard, S Odde, N Neamati - Theranostics, 2011 - ncbi.nlm.nih.gov
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes …
M Dostalek, I Gardner, BM Gurbaxani, RH Rose… - Clinical …, 2013 - Springer
Abstract Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development pipeline in the pharmaceutical industry …
DE Mager - Biochemical pharmacology, 2006 - Elsevier
Nonlinear pharmacokinetics and pharmacodynamics may result from several capacity- limited processes and often represent complicating factors in characterizing the …
P Dua, E Hawkins… - CPT: pharmacometrics & …, 2015 - Wiley Online Library
Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this …
Purpose The aim of this study is to derive and evaluate an equilibrium model of a previously developed general pharmacokinetic model for drugs exhibiting target-mediated drug …
R Deng, F Jin, S Prabhu, S Iyer - Expert opinion on drug …, 2012 - Taylor & Francis
Introduction: The number of monoclonal antibodies available for clinical use and under development has dramatically increased in the last 10 years. Understanding their …
D Ternant, G Paintaud - Expert opinion on biological therapy, 2005 - Taylor & Francis
Although monoclonal antibodies (mAbs) constitute a major advance in therapeutics, their pharmacokinetic (PK) and pharmacodynamic (PD) properties are not fully understood …
L Gibiansky, E Gibiansky - Expert opinion on drug metabolism & …, 2009 - Taylor & Francis
Models for drugs exhibiting target-mediated drug disposition (TMDD) describe biological processes in which drug-target binding significantly influences both pharmacodynamics …