Although vast numbers of putative gene regulatory elements have been cataloged, the
sequence motifs and individual bases that underlie their functions remain largely unknown …

Background DNA methylation (DNAm) age acceleration (AgeAccel) and cardiac age by 12-
lead advanced electrocardiography (A-ECG) are promising biomarkers of biological and …

MYC is a widely acting transcription factor and its deregulation is a crucial event in many
human cancers. MYC is important biologically and clinically in multiple myeloma, but the …

The relationship between genetic variation and gene expression in individual brain cell
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …

Thousands of common genetic variants in the human population have been associated with
disease risk and phenotypic variation by genome-wide association studies (GWAS) …

Recently, efforts have been made toward the harmonization of transcriptomic data structures
and workflows using the concept of data tidiness, to facilitate modularisation. We present …

Abstract The European Bioinformatics Institute (EMBL-EBI) supports life-science research
throughout the world by providing open data, open-source software and analytical tools, and …

Colorectal carcinogenesis (CRC) is caused by the gradual long-term accumulation of both
genetic and epigenetic changes. Recently, epigenetic alterations have been included in the …

Undoubtedly, single-cell RNA sequencing (scRNA-seq) has changed the research
landscape by providing insights into heterogeneous, complex and rare cell populations …

Background Macrophages and their precursors monocytes play a key role in inflammation
and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation …