Background Although considerable progress has been made towards annotating the
noncoding portion of the human and mouse genomes, regulatory elements in other species …

Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …

Cancer-associated fibroblasts (CAFs) constitute a prominent component of the tumor
microenvironment and play critical roles in cancer progression and drug resistance …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Eating disorders are complex heritable conditions influenced by both genetic and
environmental factors. Given the progress of genomic discovery in anorexia nervosa, with …

Imprinting is a critical part of normal embryonic development in mammals, controlled by
defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting …

A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …

Background DNA methylation (DNAm) may contribute to processes that underlie
associations between air pollution and poor health. Therefore, our objective was to evaluate …

Introns can be extraordinarily large and they account for the majority of the DNA sequence in
human genes. However, little is known about their population patterns of structural variation …

Platelets are small anucleate cell fragments (2–4 μm in diameter) in the blood, which play an
essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are …