Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …

Breast cancer is the most commonly diagnosed cancer (estimated 2.3 million new cases in
2020) and the leading cause of cancer death (estimated 685,000 deaths in 2020) in women …

In recent years, more and more single-cell technologies have been developed. A vast
amount of single-cell omics data has been generated by large projects, such as the Human …

Immune checkpoint therapy in breast cancer remains restricted to triple negative patients,
and long-term clinical benefit is rare. The primary aim of immune checkpoint blockade is to …

Within a tumor, cancer cells exist in different states that are associated with distinct tumor
functions, including proliferation, differentiation, invasion, metastasis, and resistance to anti …

The lung tumor microenvironment, which is composed of heterogeneous cell populations,
plays an important role in the progression of lung cancer and is closely related to therapeutic …

Recent developments have revolutionized the study of biomolecules. Among them are
molecular markers, amplification and sequencing of nucleic acids. The latter is classified into …

A robust understanding of the tumor immune environment has important implications for
cancer diagnosis, prognosis, research, and immunotherapy. Traditionally …

Neutrophil extracellular traps (NETs), a network of DNA histone complexes and proteins
released by activated neutrophils, have been demonstrated to be associated with …

Cervical cancer ranks first in female reproductive tract tumors in terms of morbidity and
mortality. Yet the curative effect of patients with persistent, recurrent or metastatic cervical …