The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

Essential fatty acids and their metabolites in the pathobiology of inflammation and its resolution

UN Das - Biomolecules, 2021 - mdpi.com
Arachidonic acid (AA) metabolism is critical in the initiation and resolution of inflammation.
Prostaglandin E2 (PGE2) and leukotriene B4/D4/E4 (LTB4/LD4/LTE4), derived from AA, are …

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

J Geng, L Chen, Y Yuan, K Wang, Y Wang… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …

COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …

Immune responses in mildly versus critically ill COVID-19 patients

H Nasrollahi, AG Talepoor, Z Saleh… - Frontiers in …, 2023 - frontiersin.org
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

SARS-CoV-2 ORF8: a rapidly evolving immune and viral modulator in COVID-19

A Arduini, F Laprise, C Liang - Viruses, 2023 - mdpi.com
The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …

Imbalanced immune response of T-cell and B-cell subsets in patients with moderate and severe COVID-19

A Golovkin, O Kalinina, V Bezrukikh, A Aquino… - Viruses, 2021 - mdpi.com
Background: The immunological changes associated with COVID-19 are largely unknown.
Methods: Patients with COVID-19 showing moderate (n= 18; SpO2> 93%, respiratory rate> …

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

AR Sarohan, M Kızıl, AÇ İnkaya, S Mahmud, M Akram… - Cellular signalling, 2021 - Elsevier
The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

The association between severe or death COVID-19 and solid organ transplantation: a systematic review and meta-analysis

G Ao, Y Wang, X Qi, B Nasr, M Bao, M Gao, Y Sun… - Transplantation …, 2021 - Elsevier
Background The effect of solid organ transplantation (SOT) on the severity and mortality of
coronavirus disease 2019 (COVID-19) remained controversial. There is still no consensus …