Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …

Simple Summary Chemotherapy has been widely used in clinic to treat various types of
tumors, although severe side effects have been the most critical limitation of this treatment …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

Background Ketone body β-hydroxybutyrate (BHB) has received more and more attentions,
because it possesses a lot of beneficial, life-preserving effects in the fields of clinical science …

Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage
of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

Pyroptosis is a caspase-dependent process relevant to the understanding of beneficial host
responses and medical conditions for which inflammation is central to the pathophysiology …

Although radiotherapy is an important clinical option available for colorectal cancer (CRC),
its use is restricted due to low radiosensitivity of CRC and high toxicity to surrounding normal …

Gasdermin B (GSDMB) belongs to a family of structurally related proteins [(ie, gasdermins
(GSDMs)]. It distinguishes itself from other members by the lack of autoinhibition but clear …