Using stem cell models to explore the genetics underlying psychiatric disorders: linking risk variants, genes, and biology in brain disease

KJ Brennand - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
There is an urgent and unmet need to advance our ability to translate genetic studies of
psychiatric disorders into clinically actionable information, which could transform diagnostics …

An atlas of genetic correlations between gestational age and common psychiatric disorders

Y Yao, C Li, P Meng, B Cheng, S Cheng, L Liu… - Autism …, 2022 - Wiley Online Library
We aim to systematically explore the potential genetic correlations between five major
psychiatric disorders and gestational ages. Genome‐wide association study (GWAS) …

[PDF][PDF] Cell type-specific and cross-population polygenic risk score analyses of MIR137 gene pathway in schizophrenia

Y Yao, W Guo, S Zhang, H Yu, H Yan, H Zhang… - Iscience, 2021 - cell.com
Cell type-specific pathway-based polygenic risk scores (PRSs) may better inform disease
biology and improve the precision of PRS-based clinical prediction. For microRNA-137 …

[HTML][HTML] Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios

J Martin, M Wray, SS Agha, KJS Lewis, RJL Anney… - Biological …, 2023 - Elsevier
Background Attention-deficit/hyperactivity disorder (ADHD) is highly heritable, but little is
known about the relative effects of transmitted (ie, direct) and nontransmitted (ie, indirect) …

[HTML][HTML] Polygenic risk of social isolation behavior and its influence on psychopathology and personality

AJ Socrates, N Mullins, RC Gur, RE Gur, E Stahl… - Molecular …, 2024 - nature.com
Social isolation has been linked to a range of psychiatric issues, but the behavioral
component that drives it is not well understood. Here, a genome-wide associations study …

Chemokine receptor 4 expression on blood T lymphocytes predicts severity of major depressive disorder

J Freff, EC Beins, L Broeker, K Schwarte… - Journal of Affective …, 2022 - Elsevier
Background Chemokines and their receptors regulate inflammatory processes in major
depressive disorder (MDD). Here, we characterize the expression pattern of the CC …

Multi‐omics cannot replace sample size in genome‐wide association studies

DAA Baranger, AS Hatoum, R Polimanti… - Genes, Brain and …, 2023 - Wiley Online Library
The integration of multi‐omics information (eg, epigenetics and transcriptomics) can be
useful for interpreting findings from genome‐wide association studies (GWAS). It has been …

[HTML][HTML] Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores

DB Kappel, SE Legge, L Hubbard, IR Willcocks… - Biological …, 2023 - Elsevier
Background Treatment-resistant schizophrenia affects approximately 30% of individuals with
the disorder. Clozapine is the medication of choice in treatment-resistant schizophrenia, but …

Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain

L Handunnetthi, D Saatci, JC Hamley… - Brain …, 2021 - academic.oup.com
Susceptibility to schizophrenia is mediated by genetic and environmental risk factors.
Maternal immune activation by infections during pregnancy is hypothesized to be a key …

Associations between plasma fatty acid concentrations and schizophrenia: a two-sample Mendelian randomisation study

HJ Jones, MC Borges, R Carnegie, D Mongan… - The lancet …, 2021 - thelancet.com
Background Although studies suggest that concentrations of omega-3 and omega-6 fatty
acids are lower in individuals with schizophrenia, evidence for beneficial effects of fatty acid …