Pleiotropy occurs when a genetic variant influences more than one trait. This is a key
property of the genomic architecture of psychiatric disorders and has been observed for rare …

Both environmental (eg interpersonal traumatization during childhood and adolescence)
and genetic factors may contribute to the development of Borderline Personality Disorder …

Schizophrenia (SCZ) is highly heterogenous and no subtypes characterizing treatment
response or longitudinal course well. Cognitive impairment is a core clinical feature of SCZ …

At present, the diagnosis of schizophrenia is based entirely on phenotype with no
established biologically based examinations for either overall diagnosis or …

Cognitive deficits are known to be related to most forms of psychopathology. Here, we
perform local genetic correlation analysis as a means of identifying independent segments …

Background Childhood psychotic-like experiences (PLEs) often precede the development of
later severe psychopathology. This study examined whether childhood PLEs are associated …

Schizophrenia is a highly heritable, polygenic disorder. A growing list of common genetic
variants have been associated with schizophrenia; there is a clear need to understand the …

Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current
techniques for generating dopaminergic neurons from human induced pluripotent stem cells …

Background Parental depression is a common and potent risk factor for depression in
offspring. However, the developmental course of depression from childhood to early …

Levels of activity are often affected in psychiatric disorders and can be core symptoms of
illness. Advances in technology now allow the accurate assessment of activity levels but it …