Schizophrenia is a serious mental illness with chronic symptoms and significant impairment
in psychosocial functioning. Although novel antipsychotics have been developed, the …

Human monozygotic (MZ) twins estimated to occur once in 250 live births, result from an
errant decision by embryonic cell (s) to develop as separate embryos. They are considered …

We have performed a genome-wide association study (GWAS) of schizophrenia in a
Norwegian discovery sample of 201 cases and 305 controls (TOP study) with a focused …

BACKGROUND: Two polymorphic regions of serotonin transporter (5-HTT) gene: a 44 base
pair (bp) insertion/deletion in the promoter region (5-HTTLPR) and a 17 bp variable number …

Serotonin 2A receptor (5-HT2A) gene was implicated to be associated with both
schizophrenia and suicidal behavior due to its role of key neurotransmitter in many …

Objective: Evidence from many different lines of research supports the hypothesis that
schizophrenia is a disorder of development with etiological factors implicated as early as the …

The mouse has many advantages over human beings for the study of genetics, including the
unique properly that genetic manipulation can be routinely carried out in the mouse …

Rationale Pharmacogenetics of schizophrenia has not yet delivered anticipated clinical
dividends. Clinical heterogeneity of schizophrenia contributes to the poor replication of the …

Computer modeling of interactions between and among cortico and subcortical areas of the
human brain, for example in a normal and a pathological state resembling schizophrenia …

Genetic isolates are exceptional resources for the detection of susceptibility genes for
complex diseases because of the potential reduction in genetic and clinical heterogeneity …