The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins.
Although it has long been thought that the substrates of ubiquitination are limited to proteins …

With the rapidly increasing incidence of bladder cancer in China and worldwide, great efforts
have been made to understand the detailed mechanism of bladder cancer tumorigenesis …

Heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L) serves as a unique E3 ligase to catalyze
the mono-ubiquitination of relevant protein or sugar substrates and plays vital roles in …

Protein ubiquitylation typically involves isopeptide bond formation between the C-terminus
of ubiquitin to the side-chain amino group on Lys residues. However, several ubiquitin …

The modification of proteins with the small protein ubiquitin constitutes a Daedalian system
of posttranslational modifications in every eukaryotic cell, which is often referred to as the …

Parkinson's disease (PD) is a progressive neurological disorder that manifests clinically as
alterations in movement as well as multiple non-motor symptoms including but not limited to …

The review comprehensively explores factors influencing enzyme activities in insects and
their implications in defense against toxicants. It encompasses a diverse array of enzymes …

The attachment of ubiquitin to a substrate (ubiquitination or ubiquitylation) impacts its lifetime
and regulates its function within the cell. Several classes of enzymes oversee the attachment …

This collection of reviews highlights the central role that ubiquitin, and ubiquitin-like proteins,
play in biology and how hypothesis driven use of new and existing biochemical tools …

The RIG-I-like receptors (RLRs), RIG-I and MDA5, are innate sensors of RNA virus infections
that are critical for mounting a robust antiviral immune response. We have shown previously …