Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine
Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
LS Sæther, T Ueland, B Haatveit, LA Maglanoc… - Molecular …, 2023 - nature.com
A potential relationship between dysregulation of immune/inflammatory pathways and
cognitive impairment has been suggested in severe mental illnesses (SMI), such as …
cognitive impairment has been suggested in severe mental illnesses (SMI), such as …
Increased prefrontal cortical cells positive for macrophage/microglial marker CD163 along blood vessels characterizes a neuropathology of neuroinflammatory …
Transcript levels of cytokines and SERPINA3 have been used to define a substantial subset
(40%) of individuals with schizophrenia with elevated inflammation and worse …
(40%) of individuals with schizophrenia with elevated inflammation and worse …
[HTML][HTML] Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain
Recent findings link cognitive impairment and inflammatory-immune dysregulation in
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis
Introduction High-inflammation subgroups of patients with psychosis demonstrate cognitive
deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C …
deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C …
Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia
Investigation of the choroid plexus in schizophrenia has seen growing interest due to its role
in the interaction between neuroinflammation and brain dysfunction. Most previous studies …
in the interaction between neuroinflammation and brain dysfunction. Most previous studies …
Investigation of the interaction between Genetic Risk Score (GRS) and fatty acid quality indices on mental health among overweight and obese women
Background & aims Mental disorders are associated with dietary fatty acids and genome-
wide association studies have found multiple risk loci robustly related to depression, anxiety …
wide association studies have found multiple risk loci robustly related to depression, anxiety …
Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders
Elevated markers of peripheral inflammation are common in psychosis spectrum disorders
and have been associated with brain anatomy, pathology, and physiology as well as clinical …
and have been associated with brain anatomy, pathology, and physiology as well as clinical …
[HTML][HTML] Electroretinographic dysfunction, insulin resistance, and childhood trauma in early-course psychosis: A case-control exploratory study
E Velez-Perez, N Raymond, C Kiely, W Molho… - Biomarkers in …, 2024 - Elsevier
Background Electroretinographic dysfunction is observed in psychosis, with a-wave and b-
wave amplitudes potentially serving as biomarkers. Insulin resistance (IR) and childhood …
wave amplitudes potentially serving as biomarkers. Insulin resistance (IR) and childhood …
Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls
LS Saether, T Ueland, B Haatveit, A Vaskinn… - medRxiv, 2024 - medrxiv.org
Background While inflammation is associated with cognitive impairment in severe mental
illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic …
illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic …