The emergence of drug resistance and metastasis has long been a difficult problem for
cancer treatment. Recent studies have shown that cancer stem cell populations are key …

Immunotherapy represented by anti-PD-(L) 1 and anti-CTLA-4 inhibitors has revolutionized
cancer treatment, but challenges related to resistance and toxicity still remain. Due to the …

Abstract N6-methyladenosine (m6A) plays a crucial role in ischemic stroke, whereas the role
of methyltransferase-like 14 (METTL14) in ischemic stroke remains unknown. A model of …

Ubiquitin Conjugating Enzyme 2C (UBE2C) is an emerging target gene for tumor
progression. However, the tumorigenic effect and mechanism of UBE2C in adrenocortical …

Background The mechanisms whereby CYFIP2 acts in tumor development and drives
immune infiltration have been poorly explored. Thus, this study aimed to identifying the role …

Previous studies have shown that epigenetic factors are involved in the occurrence and
development of rheumatoid arthritis (RA). However, the role of N 6-methyladenosine (m 6 A) …

Abstract N6-methyladenosine (m6A) is the predominant post-transcriptional RNA
modification in eukaryotes and plays a pivotal regulatory role in various aspects of RNA fate …

The importance of N6-methyladenine (m6A) in mRNA metabolism, physiology, pathology
and other life processes is well recognized. However, the exact role of m6A regulators in …

Objective Osteoarthritis (OA) is a common degenerative joint disease. The occurrence of OA
slowly destroys the soft tissue structure of the patient's joint. Severe cases could lead to …

RNA methylation, a prevalent post-transcriptional modification, has garnered considerable
attention in research circles. It exerts regulatory control over diverse biological functions by …