[HTML][HTML] A genetics-guided approach to the clinical management of schizophrenia
AD Besterman - Schizophrenia Research, 2023 - Elsevier
Schizophrenia is a highly heritable, severe mental illness characterized by hallucinations,
delusions, social withdrawal, and cognitive dysfunction present in∼ 1% of populations …
delusions, social withdrawal, and cognitive dysfunction present in∼ 1% of populations …
The landscape of the methodology in drug repurposing using human genomic data: a systematic review
L Wang, Y Lu, D Li, Y Zhou, L Yu… - Briefings in …, 2024 - academic.oup.com
The process of drug development is expensive and time-consuming. In contrast, drug
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …
[HTML][HTML] Genetic influences on circulating retinol and its relationship to human health
Retinol is a fat-soluble vitamin that plays an essential role in many biological processes
throughout the human lifespan. Here, we perform the largest genome-wide association …
throughout the human lifespan. Here, we perform the largest genome-wide association …
[HTML][HTML] Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis
A primary goal of psychiatry is to better understand the pathways that link genetic risk to
psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with …
psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with …
Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics
Cannabis use disorder (CUD) remains a significant public health issue globally, affecting up
to one in five adults who use cannabis. Despite extensive research into the molecular …
to one in five adults who use cannabis. Despite extensive research into the molecular …
Poor sleep quality in schizophrenia patients: A systematic review and meta-analyses of epidemiological and case-control studies
Objective Poor sleep quality is common in patients with schizophrenia but estimated
prevalence rates in this population have been mixed. This systematic review and meta …
prevalence rates in this population have been mixed. This systematic review and meta …
[HTML][HTML] Artificial intelligence ecosystem for computational psychiatry: Ideas to practice
XQ Liu, XY Ji, X Weng, YF Zhang - World Journal of Meta-Analysis, 2023 - wjgnet.com
Computational psychiatry is an emerging field that not only explores the biolo gical basis of
mental illness but also considers the diagnoses and identifies the underlying mechanisms …
mental illness but also considers the diagnoses and identifies the underlying mechanisms …
Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension
BACKGROUND: Hypertension is a key risk factor for major adverse cardiovascular events
but remains difficult to treat in many individuals. Dietary interventions are an effective …
but remains difficult to treat in many individuals. Dietary interventions are an effective …
Challenges, unmet needs and future directions–a critical evaluation of the clinical trial landscape in schizophrenia research
Introduction Developing novel antipsychotic mechanisms of action and repurposing
established compounds for the treatment of schizophrenia is of utmost importance to …
established compounds for the treatment of schizophrenia is of utmost importance to …
Large-Scale Mendelian Randomization Study Reveals Circulating Blood-based Proteomic Biomarkers for Psychopathology and Cognitive Task Performance
Background: Research on peripheral (eg, blood-based) biomarkers for psychiatric illness
has typically been low-throughput in terms of both the number of subjects and the range of …
has typically been low-throughput in terms of both the number of subjects and the range of …