Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …

Ferroptosis is a form of non-apoptotic cell death originally identified in cancer cells.
However, the key regulator of ferroptosis in mitochondria remains unknown. Here, we show …

Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-
inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We …

The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage,
multicompartment process that is essential for a broad range of cellular functions, including …

Bio-inspired polymeric nanochannel (also referred as nanopore)-based biosensors have
attracted considerable attention on account of their controllable channel size and shape …

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic
pH is associated with aging and neurodegenerative diseases. However, the mechanisms …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …