Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

[HTML][HTML] Microbiome and cancer

N Cullin, CA Antunes, R Straussman… - Cancer Cell, 2021 - cell.com
The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

A review of gut microbiota‐derived metabolites in tumor progression and cancer therapy

Q Yang, B Wang, Q Zheng, H Li, X Meng… - Advanced …, 2023 - Wiley Online Library
Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-κB-IL6-STAT3 axis

W Zhong, K Wu, Z Long, X Zhou, C Zhong, S Wang… - Microbiome, 2022 - Springer
Background The gut microbiota is reportedly involved in the progression and
chemoresistance of various human malignancies. However, the underlying mechanisms …

[HTML][HTML] Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies

MM Rahman, MR Islam, S Shohag, MT Ahasan… - Biomedicine & …, 2022 - Elsevier
Cancer is the world's second-leading cause of death, and the involvement of microbes in a
range of diseases, including cancer, is well established. The gut microbiota is known to play …

Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer

R Qu, Y Zhang, Y Ma, X Zhou, L Sun, C Jiang… - Advanced …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the …

Gut microbiota condition the therapeutic efficacy of trastuzumab in HER2-positive breast cancer

M Di Modica, G Gargari, V Regondi, A Bonizzi, S Arioli… - Cancer Research, 2021 - AACR
Emerging evidence indicates that gut microbiota affect the response to anticancer therapies
by modulating the host immune system. In this study, we investigated the impact of gut …

Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy

M Nenkov, Y Ma, N Gaßler, Y Chen - International journal of molecular …, 2021 - mdpi.com
Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

Local and systemic effects of microbiome‐derived metabolites

I Spivak, L Fluhr, E Elinav - EMBO reports, 2022 - embopress.org
Commensal microbes form distinct ecosystems within their mammalian hosts, collectively
termed microbiomes. These indigenous microbial communities broadly expand the genomic …

The gut microbiome, endocannabinoids and metabolic disorders

FA Iannotti, V Di Marzo - Journal of Endocrinology, 2021 - joe.bioscientifica.com
Two complex systems are emerging as being deeply involved in the control of energy
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …