Within a few years after the first successful clinical use of penicillin, investigations were
conducted in animal infection models to explore a range of factors that were considered …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

Background Owing to its low risk of adverse effects, teicoplanin has been extensively used
in patients with infections caused by MRSA. To promote the better management of patients …

Intensive care unit (ICU) patients with end-organ failure will require specialised machines or
extracorporeal therapies to support the failing organs that would otherwise lead to death …

Microneedle (MN) patches, which allow the extraction of skin interstitial fluid (ISF) without a
pain sensation, are powerful tools for minimally invasive biofluid sampling. Herein, an MN …

Introduction Estimation of vancomycin area under the curve (AUC) is challenging in the case
of discontinuous administration. Machine learning approaches are increasingly used and …

Background High-dose daptomycin is increasingly used in patients with bone and joint
infection (BJI). This raises concerns about a higher risk of adverse events (AEs), including …

The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …