SNP heritability is a marked indication for genetic gains. Extreme polygenicity, ie., small
effect-size causal SNPs, dictates as many SNPs as possible to be involved in heritability …

Polygenic scores provide an indication of an individual's genetic propensity for a trait within
a test population. These scores are calculated using results from genetic analysis conducted …

Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative
traits. We investigated associations between the fraction of the genome in runs of …

Integrating genome-wide association study with a multi-tissue transcriptome analysis provides
insights into the genetic architecture of teat traits in pigs Integrating genome-wide association …

Parametric assumptions in population genetics analysis–including linearity, sources of
population stratification and the gaussianity and additivity of errors–are often made, yet a …

Background: Whether the positive associations of smoking and alcohol consumption with
gastrointestinal diseases are causal is uncertain. We conducted this Mendelian …

Frailty is an age-related, dynamic state of multisystem physiological decline and is a strong
predictor of disability and mortality. To move towards an individualized management of …

Given the ever-growing volume and variety of biomedical data, principled analyses of these
rich datasets offer an exciting opportunity to accelerate the scientific discovery process …

Sickle cell disease (SCD) is the most common genetic disease in the United States. It is
caused by mutation of the HBB gene, which produces rigid, abnormally shaped red blood …

In the last years, Genome-Wide Associations Studies (GWAS) found many variants
associated with complex diseases. However, the biological and molecular links between …