Methods We developed an R package, comorbidPGS, which facilitates a systematic evaluation of shared genetic effects among (cor) related phenotypes using PGSs. The …
Academic achievement is partly heritable and highly polygenic. However, genetic effects on academic achievement are not independent of environmental processes. We investigated …
Efficient utilization of large-scale biobank data is crucial for inferring the genetic basis of disease and predicting health outcomes from the DNA. Yet we lack accurate statistical …
M Malanchini, Q Zhou, A Gidziela, A Allegrini… - 2024 - researchsquare.com
Academic achievement is partly heritable and highly polygenic. However, genetic effects on academic achievement are not independent of environmental processes. We investigated …
Systemic sclerosis, or scleroderma (SSc), is a complex immunemediated inflammatory disorder. SSc pathogenesis involves a triad of factors: immunological imbalance …