Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell …

Metastasis is initiated and sustained through therapy by cancer cells with stem-like and
immune-evasive properties, termed metastasis-initiating cells (MIC). Recent progress …

Although the Hippo transcriptional coactivator YAP is considered oncogenic in many tissues,
its roles in intestinal homeostasis and colorectal cancer (CRC) remain controversial. Here …

The intestinal barrier is composed of a complex cell network defining highly
compartmentalized and specialized structures. Here, we use spatial transcriptomics to …

Damage to the intestinal stem cell niche can result from mechanical stress, infections,
chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to …

Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and
relationship to primary-tumor-initiating stem cells are not known. We show that L1CAM+ …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Acute kidney injury (AKI) is strongly associated with mortality, independently of its cause.
The kidney contributes to up to 40% of systemic glucose production by gluconeogenesis …

Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key
component of organoid growth media yet is dispensable for intestinal homeostasis …