Intestinal stem cells (ISCs) maintain the epithelial lining of the intestines, but mechanisms
regulating ISCs and their niche after damage remain poorly understood. Utilizing radiation …

The ability of stem cells to divide and differentiate is necessary for tissue repair and
homeostasis. Appropriate spatial and temporal mechanisms are needed. Local intercellular …

Wnt signalling induces a gradient of stem/progenitor cell proliferation along the crypt‐villus
axis of the intestine, which becomes expanded during intestinal regeneration or tumour …

Enteric helminths form intimate physical connections with the intestinal epithelium, yet their
ability to directly alter epithelial stem cell fate has not been resolved. Here we demonstrate …

The intestinal tract is lined by a single layer of epithelium that is one of the fastest
regenerating tissues in the body and which therefore requires a very active and exquisitely …

The Hippo pathway and its downstream effectors, the transcriptional coactivators Yes-
associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) …

Abstract Background Wu-Mei-Wan (WMW), a traditional Chinese medicine, has been
applied in the treatment of gastrointestinal diseases with long-term diarrhea and …

The progeny of intestinal stem cells (ISCs) dedifferentiate in response to ISC attrition. The
precise cell sources, transitional states, and chromatin remodeling behind this activity …

Intestinal stem cells (ISCs) at the crypt base are responsible for the regeneration of the
intestinal epithelium. However, how ISC self‐renewal is regulated still remains unclear. Here …

Effective tissue repair requires coordinated intercellular communication to sense damage,
remodel the tissue, and restore function. Here, we dissected the healing response in the …