Memory B cells (MBCs) have a crucial function in providing an enhanced response to
repeated infections. Upon antigen encounter, MBC can either rapidly differentiate to …

Antigen-specific class-switched antibodies are detected at the same time or even before IgM
in serum of non-vaccinated individuals infected with SARS-CoV-2. These derive from the …

This work examines cellular immunity against SARS-CoV-2 in patients from Córdoba,
Argentina, during two major waves characterized by different circulating viral variants and …

Despite extensive research on severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2) vaccination responses in healthy individuals, there is comparatively little known …

The functional programs chosen by B and T cell clones fundamentally determine the
architecture of immune response to distinct challenges. Advances in scRNA-Seq have …

The continued evolution of SARS-CoV-2 underscores the need to understand qualitative
aspects of the humoral immune response elicited by spike immunization. Here, we …

Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved
clinical outcomes of patients with relapsed or refractory hematologic malignancies …

The ability of antibodies to block infections makes them highly relevant for successful
vaccine development. Through the papers described in this thesis, I attempt to characterize …

The lymphocytes (B and T cells) of the adaptive immune system undergo variable (V),
diversity (D), and junctional (J) gene recombination, resulting in highly diverse antigen …

Functional programs selected by Th lymphocytes control the course of primary and any
further secondary immune responses. The functional differentiation of Th subsets starts …