[HTML][HTML] Current and novel biomarkers of thrombotic risk in COVID-19: a consensus statement from the international COVID-19 thrombosis biomarkers colloquium

DA Gorog, RF Storey, PA Gurbel, US Tantry… - Nature Reviews …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and
thromboembolic events, owing to excessive inflammation, endothelial cell activation and …

[HTML][HTML] Long Covid: where we stand and challenges ahead

A Mantovani, MC Morrone, C Patrono… - Cell Death & …, 2022 - nature.com
Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and
colloquially as Long Covid, has been defined as a constellation of signs and symptoms …

[HTML][HTML] The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

JD Domizio, MF Gulen, F Saidoune, VV Thacker… - Nature, 2022 - nature.com
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

JW Guarnieri, JM Dybas, H Fazelinia, MS Kim… - Science translational …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

[HTML][HTML] SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

NC Gassen, J Papies, T Bajaj, J Emanuel… - Nature …, 2021 - nature.com
Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …

[HTML][HTML] Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

MN Soares, M Eggelbusch, E Naddaf… - Journal of cachexia …, 2022 - Wiley Online Library
Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

[PDF][PDF] Large-scale multi-omic analysis of COVID-19 severity

KA Overmyer, E Shishkova, IJ Miller, J Balnis… - Cell systems, 2021 - cell.com
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

[HTML][HTML] The coding capacity of SARS-CoV-2

Y Finkel, O Mizrahi, A Nachshon… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …