Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
COVID‐19 and toll‐like receptor 4 (TLR4): SARS‐CoV‐2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation
MM Aboudounya, RJ Heads - Mediators of inflammation, 2021 - Wiley Online Library
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
Evasion of type I interferon by SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …
Heightened innate immune responses in the respiratory tract of COVID-19 patients
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …
infection have posed a severe threat to global public health. It is unclear how the human …
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Abstract The chr12q24. 13 locus encoding OAS1–OAS3 antiviral proteins has been
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
COVID-19: the inflammation link and the role of nutrition in potential mitigation
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 …
syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 …
Type 1 interferons as a potential treatment against COVID-19
Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a
clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the …
clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the …
Structural characterization of SARS-CoV-2: where we are, and where we need to be
G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …
humans in almost every country, causing the disease COVID-19. Since the start of the …
The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
Main components of fish immunity: An overview of the fish immune system
DM Mokhtar, G Zaccone, A Alesci, M Kuciel… - Fishes, 2023 - mdpi.com
Cellular immune responses consist of innate and adaptive cell-mediated immune
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
mechanisms, where all leukocyte subpopulations are included. Among these are vital …