Globally, there is a huge unmet need for effective treatments for neurodegenerative
diseases. The complexity of the molecular mechanisms underlying neuronal degeneration …

TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …

To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD …

Genetic and genomic studies have advanced our knowledge of inherited Parkinson's
disease (PD), however, the etiology and pathophysiology of idiopathic PD remain unclear …

Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2)
have been shown to increase the risk of developing Alzheimer's disease (AD) supporting a …

Introduction The inositol polyphosphate‐5‐phosphatase D (INPP5D) gene encodes a dual‐
specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins …

Alzheimer's disease (AD) is the most common dementia type affecting nearly 44 million
people worldwide. Recent findings point to microglia as a significant contributor to neural …

Abstract Background Alzheimer's Disease (AD) is a neurodegenerative disorder influenced
by aging and genetic risk factors. The inheritance of APOE ε4 and variants of Triggering …