[HTML][HTML] Totipotency of mouse zygotes extends to single blastomeres of embryos at the four-cell stage

M Maemura, H Taketsuru, Y Nakajima, R Shao… - Scientific reports, 2021 - nature.com
In multicellular organisms, oocytes and sperm undergo fusion during fertilization and the
resulting zygote gives rise to a new individual. The ability of zygotes to produce a fully …

The mammalian preimplantation embryo: its role in the environmental programming of postnatal health and performance

MA Velazquez, A Idriss, P Chavatte-Palmer… - Animal Reproduction …, 2023 - Elsevier
During formation of the preimplantation embryo several cellular and molecular milestones
take place, making the few cells forming the early embryo vulnerable to environmental …

Reprogramming the genome to totipotency in mouse embryos

L Zhou, J Dean - Trends in cell biology, 2015 - cell.com
Despite investigative interest, the artificial derivation of pluripotent stem cells remains
inefficient and incomplete reprogramming hinders its potential as a reliable tool in …

Mesenchymal stem cells as a source of dopaminergic neurons: a potential cell based therapy for Parkinson's disease

K Venkatesh, D Sen - Current Stem Cell Research & Therapy, 2017 - ingentaconnect.com
Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease
depend on well-characterized dopaminergic neuronal candidates that are healthy and show …

[HTML][HTML] The initiation of mammalian embryonic transcription: to begin at the beginning

ACF Perry, M Asami, BYH Lam, GSH Yeo - Trends in cell biology, 2023 - cell.com
Gamete (sperm and oocyte) genomes are transcriptionally silent until embryonic genome
activation (EGA) following fertilization. EGA in humans had been thought to occur around the …

[HTML][HTML] Totipotency segregates between the sister blastomeres of two-cell stage mouse embryos

E Casser, S Israel, A Witten, K Schulte, S Schlatt… - Scientific reports, 2017 - nature.com
Following fertilization in mammals, it is generally accepted that totipotent cells are exclusive
to the zygote and to each of the two blastomeres originating from the first mitotic division …

[HTML][HTML] A program of successive gene expression in mouse one-cell embryos

M Asami, BYH Lam, M Hoffmann, T Suzuki, X Lu… - Cell Reports, 2023 - cell.com
At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …

[HTML][HTML] Stem cells: innovative therapeutic options for neurodegenerative diseases?

G Bonaventura, A Munafò, CM Bellanca, V La Cognata… - Cells, 2021 - mdpi.com
Neurodegenerative diseases are characterized by the progressive loss of structure and/or
function of both neurons and glial cells, leading to different degrees of pathology and loss of …

[HTML][HTML] Buckwheat in tissue culture research: current status and future perspectives

A Tomasiak, M Zhou, A Betekhtin - International Journal of Molecular …, 2022 - mdpi.com
Buckwheat is a member of a genus of 23 species, where the two most common species are
Fagopyrum esculentum (common buckwheat) and Fagopyrum tataricum (Tartary …

[HTML][HTML] Unlocking the potential of stem cells: Their crucial role in the production of cultivated meat

DK Lee, M Kim, J Jeong, YS Lee, JW Yoon… - Current Research in …, 2023 - Elsevier
Cellular agriculture is an emerging research field of agribiotechnology that aims to produce
agricultural products using stem cells, without sacrificing animals or cultivating crops …