The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

As the worldwide population ages, oncologists are often required to make difficult and
complex decisions regarding the treatment of older people (aged 65 years and older) with …

UK Biobank is a health resource with data from over 500,000 adults. The cognitive
assessment in UK Biobank is brief and bespoke, and is administered without supervision on …

ABSTRACT BACKGROUND AND OBJECTIVE As the proportion of aging people in our
population increases steadily, global strategies accompanied by extensive research are …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …