Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …

DNA comprises molecular information stored in genetic and epigenetic bases, both of which
are vital to our understanding of biology. Most DNA sequencing approaches address either …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …

Heterologous organ transplantation is an effective way of replacing organ function but is
limited by severe organ shortage. Although generating human organs in other large …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

A formal demonstration that mammalian pluripotent stem cells possess preimplantation
embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …